Iakovleva I A, Chernyĭ A P
Arkh Patol. 1982;44(6):20-6.
Some ultrastructural features of cervical dysplasia and carcinoma in situ were revealed by electron microscopic studies of cervix specimens from 24 women. Both types of preinvasive disorders are characterized by alterations in the distribution of nuclear chromatin, the outline of the nuclear membrane, the amount of cytoplasmic organelles, and the mode of cellular attachment. Unlike dysplasia, a great variety of morphological patterns was found in carcinoma in situ which could be subdivided into squamous and reserve cell types. In carcinoma in situ, there was no increase in differentiation of cells and the cell surface up to the outermost layers. The basal membrane was altered only in carcinoma in situ epithelium. The ability of the epithelial cell processes to penetrate through the altered basal membrane and to invade the underlying stroma may be the evidence of the malignancy of cells in carcinoma in situ but not in dysplasia where the basal membrane was unaltered.
通过对24名女性宫颈标本的电子显微镜研究，揭示了宫颈发育异常和原位癌的一些超微结构特征。这两种类型的浸润前疾病的特征是核染色质分布、核膜轮廓、细胞质细胞器数量以及细胞附着方式的改变。与发育异常不同，原位癌中发现了多种形态学模式，可细分为鳞状细胞型和储备细胞型。在原位癌中，直至最外层细胞的分化和细胞表面均无增加。基底膜仅在原位癌上皮中发生改变。上皮细胞突起穿透改变的基底膜并侵入下方基质的能力可能是原位癌细胞恶性的证据，但发育异常中基底膜未改变则不存在这种情况。
