Summers M P
J Pharm Sci. 1978 Nov;67(11):1606-10. doi: 10.1002/jps.2600671126.
Glasses were prepared from a number of barbiturates. The viscosities and glass transition temperatures of the glasses were dependent on the structure of the groups present on the C-5 and N-1 atoms. Solid dispersions were prepared from three selected barbiturates formulated with citric acid. The glass transition temperatures of these systems indicated that a 1:1 molar ratio complex was formed between the two components and that intermolecular bonding was stronger in the complex than in the individual components.
玻璃是由多种巴比妥酸盐制备而成的。这些玻璃的粘度和玻璃化转变温度取决于C - 5和N - 1原子上所存在基团的结构。固体分散体是由三种选定的与柠檬酸配制的巴比妥酸盐制备而成的。这些体系的玻璃化转变温度表明，两种组分之间形成了1:1摩尔比的络合物，且该络合物中的分子间键合比各单独组分中的更强。
