Schneider H, Nightingale C H, Quintiliani R, Flanagan D R
J Pharm Sci. 1978 Nov;67(11):1620-2. doi: 10.1002/jps.2600671130.
The antibiotic cephalexin was formulated as an oral prolonged-release tablet and evaluated by in vitro dissolution testing as well as in vivo in 10 human subjects. Comparisons were made of the time course of the blood levels among the prolonged-release formulation, the commercially available capsule, and intravenous administration. Even though lower peak blood levels were attained in the prolonged-release tablet, absorption continued for at least 6 hr. Comparison with in vitro dissolution data showed that absorption was dissolution rate limited. Bioavailability comparisons showed that the prolonged-release formulation was completely available, as was the commercial oral capsule.
抗生素头孢氨苄被制成口服缓释片，并通过体外溶出度测试以及在10名人类受试者体内进行评估。对缓释制剂、市售胶囊和静脉给药的血药浓度时间过程进行了比较。尽管缓释片中达到的血药峰浓度较低，但吸收至少持续6小时。与体外溶出数据比较表明，吸收受溶出速率限制。生物利用度比较表明，缓释制剂与市售口服胶囊一样完全可用。
