The effect of a combination of timolol, hydrochlorothiazide and amiloride on 24 hour blood pressure control using ambulatory intra-arterial monitoring.

1 The effectiveness of fixed combination tablets of timolol 10 mg, hydrochlorothiazide 25 mg and amiloride 2.5 mg (Moducren) once daily in the control of blood pressure has been assessed in fully ambulant hypertensives by the technique of continuous intra-arterial recording. Highly significant blood pressure reduction (P less than 0.001) was obtained consistently throughout the whole day, confirming the potency and usefulness of the preparation for those patients who need more than one drug to control their blood pressure. 2 Blood pressure responses to both isometric and dynamic forms of exercise were also significantly lowered by combination therapy. 3 The addition of a diuretic to a beta-adrenoceptor blocker appears to be an advantage if the aim of treatment in hypertension is 24 h blood pressure control.