甲苯咪唑在人体内的药代动力学和生物利用度：一项使用[³H] - 甲苯咪唑的初步研究。
The pharmacokinetics and bioavailability of mebendazole in man: a pilot study using [3H]-mebendazole.
作者信息
Dawson M, Allan R J, Watson T R
出版信息
Br J Clin Pharmacol. 1982 Sep;14(3):453-5. doi: 10.1111/j.1365-2125.1982.tb02008.x.
Abstract
Following the intravenous administration of a tracer dose (1.7 microgram) of [3H]-mebendazole to a man, an elimination half-life of 1.16 h was observed and the volume of distribution was calculated to be 2.03 l/kg. After oral administration of the same dose, an elimination half-life of 0.74 h was observed. The bioavailability of mebendazole from the solution was found to be 17%.
摘要
给一名男性静脉注射微量示踪剂量（1.7微克）的[³H] - 甲苯咪唑后，观察到消除半衰期为1.16小时，计算得出分布容积为2.03升/千克。口服相同剂量后，观察到消除半衰期为0.74小时。发现甲苯咪唑溶液的生物利用度为17%。
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3
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4
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