Jones G L, Neill A R
Biochim Biophys Acta. 1982 Aug 18;712(2):420-6. doi: 10.1016/0005-2760(82)90362-9.
Clofibrate-treated mice showed a significant decrease in plasma triacylglycerols and a parallel elevation of liver catalase. Repeated administration of aminotriazole to clofibrate-treated mice effectively abolished the elevated catalase activity, but had no significant effect on the reduced plasma triacylglycerol levels. In mice, the hypolipidemic effect of clofibrate may be dissociated from its capacity to elevate liver catalase. Repeated administration of aminotriazole to control mice resulted in significantly lowered carcass fat and plasma triacylglycerol levels even though the liver catalase activity was greatly depressed. The livers of clofibrate-treated mice showed an increase in phospholipid content. Livers of aminotriazole-treated mice showed a decrease in total lipid content, with a profound decrease in free fatty acids and triacylglycerols and a slight increase in phospholipids. The composition of the individual free fatty acids of the liver triacylglycerols showed a shift towards the shorter fatty acids and the nutritionally essential alpha-linolenic acid in clofibrate-treated mice.
氯贝丁酯处理的小鼠血浆三酰甘油显著降低，同时肝脏过氧化氢酶水平相应升高。对氯贝丁酯处理的小鼠重复给予氨基三唑可有效消除升高的过氧化氢酶活性，但对降低的血浆三酰甘油水平无显著影响。在小鼠中，氯贝丁酯的降血脂作用可能与其提高肝脏过氧化氢酶的能力无关。对对照小鼠重复给予氨基三唑，即使肝脏过氧化氢酶活性大幅降低，也会导致胴体脂肪和血浆三酰甘油水平显著降低。氯贝丁酯处理的小鼠肝脏磷脂含量增加。氨基三唑处理的小鼠肝脏总脂质含量降低，游离脂肪酸和三酰甘油大幅减少，磷脂略有增加。氯贝丁酯处理的小鼠肝脏三酰甘油中各个游离脂肪酸的组成向较短链脂肪酸和营养必需的α-亚麻酸转变。
