Resko J A, Goy R W, Robinson J A, Norman R L
Biol Reprod. 1982 Sep;27(2):354-61. doi: 10.1095/biolreprod27.2.354.
Forty-eight untreated rhesus females (Macaca mulatta) were studied from birth until menarche and for the 12 intermenstrual periods following menarche. The 48 animals were studied in two subsets: one in Oregon (N = 22) and the other in Wisconsin (N = 26). The Oregon animals menstruated 127.3 +/- 6.6 (SEM) weeks after birth, whereas the Wisconsin animals reached menarche 133.0 +/- 3.1 weeks postnatum. These ages did not differ significantly nor was there a significant difference in mean body weight at menarche between the two groups. A linear pattern of ponderal growth was observed from birth to menarche with an acceleration in ponderal growth closely following menarche. The first 12 cycles after menarche gradually decreased in length from 13.0 to 13.6 weeks (range between groups) for the first intermenstrual interval to 4.9 to 6.1 weeks (range between groups) for the 12th cycle. In these cycles the percentage of animals ovulating gradually increased with time (0% in cycle 1, 6.3% in cycle 2, 50% in cycle 8 and 90% in cycle 12). These data showed a significant linear correlation (r = 0.9328, P less than 0.01). Although cycle lengths in adults were significantly greater during June through August than during the rest of the year, no effect of season could be ascertained in the pubescent animals. Serum samples from two animals bled frequently from the onset of menarche through the first ovulatory cycle contained preovulatory amounts of estradiol-17 beta in anovulatory cycles. This suggests that follicle growth in occurring but ovulation does not occur during the early cycles of adolescence. These data support the concept that recovery from adolescent sterility in rhesus monkeys takes approximately 18 months and that recovery occurs in a nearly linear fashion within a given population. We hypothesize that the inability of a young female to ovulate reflects an inability to respond to ovarian estrogen by releasing ovulatory amounts of gonadotropin.
对48只未经处理的恒河猴雌性（猕猴）从出生直至初潮，并在初潮后的12个月经周期进行了研究。48只动物被分为两个亚组进行研究：一组在俄勒冈州（N = 22），另一组在威斯康星州（N = 26）。俄勒冈州的动物在出生后127.3±6.6（标准误）周月经初潮，而威斯康星州的动物在出生后133.0±3.1周达到初潮。这两个年龄组之间没有显著差异，且两组初潮时的平均体重也没有显著差异。从出生到初潮观察到体重增长呈线性模式，初潮后体重增长加速。初潮后的前12个周期长度逐渐缩短，从第一个月经周期的13.0至13.6周（组间范围）到第12个周期的4.9至6.1周（组间范围）。在这些周期中，排卵动物的百分比随时间逐渐增加（第1周期为0%，第2周期为6.3%，第8和9周期为50%，第12周期为90%）。这些数据显示出显著的线性相关性（r = 0.9328，P < 0.01）。尽管成年动物的周期长度在6月至8月期间显著长于一年中的其他时间，但在青春期动物中未发现季节影响。从初潮开始至第一个排卵周期频繁采血的两只动物的血清样本，在无排卵周期中含有排卵前水平的雌二醇-17β。这表明青春期早期卵泡在生长，但排卵未发生。这些数据支持了恒河猴青春期不育恢复大约需要18个月且在特定群体中以近似线性方式发生的概念。我们假设年轻雌性无法排卵反映了其无法通过释放排卵量的促性腺激素来对卵巢雌激素作出反应。
