Schaison G
Biomed Pharmacother. 1982 Mar;36(2):74-6.
The occurrence of a transitory aplasia followed shortly thereafter by an acute leukemia in a known sequence in children is rare. We report 13 observations involving children between 6 months and 10 years of age. Splenomegaly was observed in 5 patients and hepatomegaly in two. There was a tricytopenia in 5 cases, bicytopenia in 4 and an isolated cytopenia in the remaining 4 cases. The phase of aplasia was short, lasting from 6 to 30 days. Complete bone marrow recovery occurred with integral restitution. Remission was spontaneous or followed transfusion or corticosteroid therapy and lasted for 2 to 6 months. The leukemia had no particular character when it appeared: there was one acute myeloblastic leukemia, 11 acute lymphoblastic cases and one sarcoma. Median survival time was 5 to 32 months and relapses were not aplasic. It is noteworthy that among these cases there are two long remissions lasting more than ten years. The interpretation of these observations is difficult because of the following choice: an initially non-leukemic aplasia or a leukemia present at the onset but undetected, camouflaged or confined to several infrequent blast cell islets.
儿童中短暂性再生障碍随后不久按已知顺序发生急性白血病的情况很少见。我们报告了13例6个月至10岁儿童的观察病例。5例患者出现脾肿大，2例出现肝肿大。5例出现全血细胞减少，4例出现双血细胞减少，其余4例出现单一血细胞减少。再生障碍期较短，持续6至30天。骨髓完全恢复，恢复完整。缓解是自发的，或在输血或皮质类固醇治疗后出现，持续2至6个月。白血病出现时无特殊特征：1例急性髓细胞白血病，11例急性淋巴细胞白血病病例，1例肉瘤。中位生存时间为5至32个月，复发时无再生障碍表现。值得注意的是，这些病例中有2例长期缓解持续超过10年。由于以下选择，对这些观察结果的解释很困难：最初的非白血病性再生障碍或起病时存在但未被检测到、被掩盖或局限于几个罕见原始细胞岛的白血病。
