Vetoshkin A V, Fomenko A M, Zozulia A A
Biull Eksp Biol Med. 1982 Jul;94(7):52-3.
The radioreceptor method was used to find high affinity, saturable and partially reversible specific binding of 3H-5HT with a gross membrane fraction of human peripheral blood lymphocytes. The Sketchard analysis demonstrated the presence of two types of the binding sites with equilibrium dissociation constants 2 nM and 66 nM. These characteristics are similar to those of 3H-5HT binding with the brain receptors. The results obtained suggest the existence on human lymphocytes of two types of serotonin receptors.
采用放射受体法研究了3H-5羟色胺（3H-5HT）与人外周血淋巴细胞粗膜组分的高亲和力、可饱和且部分可逆的特异性结合。斯卡查德分析表明存在两种结合位点，其平衡解离常数分别为2 nM和66 nM。这些特性与3H-5HT与脑受体结合的特性相似。所得结果提示人淋巴细胞上存在两种类型的5-羟色胺受体。
