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[内源性儿茶酚胺与刺激加速神经时的心脏功能]

[Endogenous catecholamines and heart function in stimulation of the accelerator nerve].

作者信息

Shvetsov I M, Bobkova V M, Rodina L G, Kiseleva Z M

出版信息

Biull Eksp Biol Med. 1982 Jul;94(7):8-11.

PMID:7126832
Abstract

The role of catecholamines in realization of the effects of the augmenting cardiac nerve has been studied during acute experiments on dogs anesthesized with hexenal. Activation of pump function and myocardial contractility during nerve stimulation has been shown to be in good agreement with the increased noradrenaline concentration in the coronary sinus blood. The synthesis of adrenaline has not been found to lag behind its consumption upon the exposure described. Nerve stimulation has led to accumulation of myocardial adrenaline which takes part in realization of a positive inotropic effect to a far less extent than noradrenaline, and exerts no adverse action on cardiac function.

摘要

在使用己烯醛麻醉的犬急性实验中,研究了儿茶酚胺在增强心神经效应实现过程中的作用。已表明,神经刺激期间泵功能和心肌收缩性的激活与冠状窦血中去甲肾上腺素浓度的增加高度一致。未发现肾上腺素的合成在所述暴露后落后于其消耗。神经刺激导致心肌肾上腺素的积累,其在正性肌力作用的实现中所起的作用远小于去甲肾上腺素,并且对心脏功能无不良作用。

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