英国的遗传学家对杜氏肌营养不良症的遗传风险进行计算。
Calculation of genetic risks in Duchenne muscular dystrophy by geneticists in the United Kingdom.
作者信息
Bundey S
出版信息
J Med Genet. 1978 Aug;15(4):249-53. doi: 10.1136/jmg.15.4.249.
Abstract
Pedigrees of Duchenne muscular dystrophy were sent to 32 geneticists in the United Kingdom, asking for their calculations for genetic risks for female relatives. Eighteen participated, of whom only 7 gave correct answers for all pedigrees. The method most used for calculations (the 'Bayesian' method) was most liable to errors in new situations. An alternative, simpler method is presented.
摘要
杜兴氏肌营养不良症的系谱被发送给英国的32位遗传学家，要求他们计算女性亲属的遗传风险。18人参与了，其中只有7人对所有系谱都给出了正确答案。计算中最常用的方法（“贝叶斯”方法）在新情况下最容易出错。本文提出了一种替代的、更简单的方法。
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本文引用的文献
1
Formal genetics of muscular dystrophy.肌营养不良症的形式遗传学
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CREATINE KINASE LEVELS IN WOMEN WHO CARRY GENES FOR THREE TYPES OF MUSCULAR DYSTROPHY.携带三种肌肉萎缩症基因的女性的肌酸激酶水平。
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Heredity counselling for sex-linked recessive deficiency diseases.性连锁隐性缺陷疾病的遗传咨询。
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Genetic counselling in lethal X-linked disorders.致死性X连锁疾病的遗传咨询
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