显性尖头并指畸形的连锁分析
Linkage analysis in dominant acrocephalosyndactyly.
作者信息
Eastman J R, Escobar V, Bixler D
出版信息
J Med Genet. 1978 Aug;15(4):292-3. doi: 10.1136/jmg.15.4.292.
Abstract
Linkage analysis was performed on a previously reported family in which multiple dominantly inherited acrocephalosyndactyly syndromes were present. An underlying axiom of linkaged analysis is that the trait analysed be monogenic. This prerequisite was presumptively established in the single kindred analysed because acrocephalosyndactyly was observed in multiple cases in multiple generations.
摘要
对一个先前报道的家族进行了连锁分析，该家族中存在多种显性遗传的尖头并指综合征。连锁分析的一个基本公理是所分析的性状为单基因性状。在分析的单个家系中假定满足了这一前提条件，因为在多代的多个病例中都观察到了尖头并指现象。
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