Hearn T L, Hannon W H
Clin Chem. 1982 Oct;28(10):2022-5.
Screening of newborns for hypothyroidism is mandated by law in most states. The screening usually consists of measuring thyroxin in dried blood spot specimens followed by measurement of thyrotropin if the results for thyroxin are suggestive of hypothyroidism. The first nationwide interlaboratory surveys designed to assess the proficiency of screening laboratories in the identification of euthyroid and hypothyroid specimens are reported here. Each survey consisted of three specimens mailed quarterly from late 1979 through 1980. A total of 88 laboratories participated in at least one of the four surveys. More than 17 different methods or diagnostic kits were used by participants in the surveys. Coefficients of variation ranged from 20% to 41% for thyroxin data and from 23% to 63% for thyrotropin. Despite the large analytical interlaboratory variation, most participants assigned clinical classifications consistent with the survey design. The incidence of mis-classifications was low.
大多数州法律规定对新生儿进行甲状腺功能减退筛查。筛查通常包括测量干血斑标本中的甲状腺素，如果甲状腺素结果提示甲状腺功能减退，则接着测量促甲状腺激素。本文报道了首次旨在评估筛查实验室识别甲状腺功能正常和甲状腺功能减退标本能力的全国性实验室间调查。每次调查包括从1979年末到1980年每季度邮寄的三个标本。共有88个实验室参与了四项调查中的至少一项。调查参与者使用了超过17种不同的方法或诊断试剂盒。甲状腺素数据的变异系数在20%至41%之间，促甲状腺激素的变异系数在23%至63%之间。尽管实验室间分析差异很大，但大多数参与者给出的临床分类与调查设计一致。错误分类的发生率很低。
