饮食限制和蛋白质缺乏对大鼠体内四环素血浆半衰期及组织分布的影响。

Influence of dietary restriction and protein deficiency on plasma half-life and tissue distribution of tetracycline in rats.

Raghuram T C, Krishnaswamy K, Rao K V

Clin Exp Pharmacol Physiol. 1982 Mar-Apr;9(2):139-44. doi: 10.1111/j.1440-1681.1982.tb00790.x.

Abstract

The effects of dietary restriction and protein deficiency on plasma half-life and tissue distribution of tetracycline were studied in rats by feeding either a 20% protein diet in restricted quantity or a 9% protein diet ad lib and compared with rats given a 20% protein diet ad lib (control group). 2. It was observed that half-life of tetracycline was shortened and that plasma and tissue Cmin levels at steady-state were lower in undernourished rats. Tissue concentrations in liver, kidney, muscle and bone correlated well with plasma levels. A high degree of correlation was also observed between plasma and tonsillar concentrations of tetracycline in human subjects. 3. These studies indicate that undernourished subjects may require an altered dosage regimen of tetracycline to maintain effective steady-state concentrations of the drug.

摘要

通过给大鼠喂食限量的20%蛋白质饮食或随意采食的9%蛋白质饮食，研究了饮食限制和蛋白质缺乏对四环素血浆半衰期和组织分布的影响，并与随意采食20%蛋白质饮食的大鼠（对照组）进行比较。2. 观察到营养不良大鼠的四环素半衰期缩短，稳态时血浆和组织最低浓度较低。肝脏、肾脏、肌肉和骨骼中的组织浓度与血浆水平密切相关。在人类受试者中，四环素的血浆浓度与扁桃体浓度之间也观察到高度相关性。3. 这些研究表明，营养不良的受试者可能需要改变四环素的给药方案，以维持药物有效的稳态浓度。