Urban J P, Holm S, Maroudas A, Nachemson A
Clin Orthop Relat Res. 1982 Oct(170):296-302.
Adult dogs were injected intravenously with 35S-sulphate, and moderately exercised for one to six hours to measure isotope concentrations and profiles throughout the intervertebral discs. The isotope profiles were also observed in control animals that had been under anesthesia between injections and death. In both sets of animals, the profiles were in agreement with those expected for isotope transport by diffusion. This agreement indicates that fluid "pumping" during movement has an insignificant effect on transport of nutrients into the disc. Small solutes, e.g., O2, glucose, and sulphate, are transported into the disc chiefly by diffusion. However, calculations show that because of their low diffusivities, "pumping" may increase the rate of transport of large solutes into the disc, as it does in articular cartilage.
给成年犬静脉注射35S-硫酸盐，并适度运动1至6小时，以测量整个椎间盘内的同位素浓度和分布情况。在注射与死亡之间处于麻醉状态的对照动物中也观察到了同位素分布情况。在这两组动物中，其分布情况与通过扩散进行同位素运输所预期的情况一致。这种一致性表明，运动过程中的液体“泵吸”对营养物质进入椎间盘的运输影响不大。小溶质，如氧气、葡萄糖和硫酸盐，主要通过扩散进入椎间盘。然而，计算表明，由于它们的扩散系数较低，“泵吸”可能会增加大溶质进入椎间盘的运输速率，就像在关节软骨中一样。
