Burden H W, Gorewit R C, Louis T M, Muse P D, Lawrence I E
Endokrinologie. 1982 Jul;79(3):379-84.
To determine if oxytocin and estradiol were effected by pelvic neurectomy (PN), utero-ovarian vein blood was collected from PN rats during the preparturient period and assayed for these hormones. Radioimmunoassayable oxytocin levels were not significantly different in any groups of sham operated (S) or PN animals on days 21 and 22 or PN animals on days 23 and 24. Estradiol (E2) levels rose significantly on day 22 in S animals but there was no significant change in E2 in PN rats throughout the time period studied, although E2 levels were generally high. These results indicate that the blocked parturition characteristic of PN animals cannot be attributed to altered oxytocin levels. The lack of a significant E2 surge on day 22 in PN rats may contribute to the failure of utero-ovarian vein prostaglandin F levels to rise in these animals during the preparturient period.
为了确定催产素和雌二醇是否受盆腔神经切除术（PN）的影响，在产前从接受PN手术的大鼠收集子宫卵巢静脉血并检测这些激素。在第21天和第22天，假手术（S）组或PN组动物以及第23天和第24天的PN组动物中，可通过放射免疫分析检测的催产素水平在任何组间均无显著差异。S组动物在第22天雌二醇（E2）水平显著升高，但在整个研究时间段内，PN大鼠的E2没有显著变化，尽管E2水平总体较高。这些结果表明，PN动物分娩受阻的特征不能归因于催产素水平的改变。PN大鼠在第22天缺乏显著的E2激增可能导致这些动物在产前子宫卵巢静脉前列腺素F水平未能升高。
