Balibrea J L, Canela M, Salva J A, Puig M, Schwartz S, Rull M
Eur Surg Res. 1982 Sep-Oct;14(5):377-85. doi: 10.1159/000128310.
In this work we have studied the gastric mucosal energy metabolism in the restraint-rat experimental model. Gastric mucosal concentrations of glucose, AMP, ADP and ATP were determined, as well as free fatty acids and cholesterol, in order to evaluate alterations in the phospholipid composition of the cell membrane. We have observed a progressive decrease of glucose levels and an increase of ATP and Atkinson's index following 24 h of restraint; this finding refers to ATP not being used in HCl synthesis, and to activation of protein-kinase in the parietal cells due to an increase of histamine in the gastric mucosa. The increase in free fatty acids and a marked decrease of cholesterol in glandular mucosa suggest an alteration in the membrane phospholipid composition as a result of local phospholipases activated by histamine.
在这项研究中，我们在束缚大鼠实验模型中研究了胃黏膜能量代谢。测定了胃黏膜中葡萄糖、AMP、ADP和ATP的浓度，以及游离脂肪酸和胆固醇的浓度，以评估细胞膜磷脂组成的变化。我们观察到，束缚24小时后，葡萄糖水平逐渐降低，ATP和阿特金森指数升高；这一发现表明，ATP未用于盐酸合成，且由于胃黏膜中组胺增加，壁细胞中的蛋白激酶被激活。腺性黏膜中游离脂肪酸增加和胆固醇显著降低，表明组胺激活局部磷脂酶导致膜磷脂组成发生改变。
