Pravdivtsev V A, Komendantova M V, Iasnetsov V V, Osipov N M
Farmakol Toksikol. 1982 Jul-Aug;45(4):13-6.
It has been established in experiments on conscious cats that variation in spontaneous activity of the midbrain reticular formation neurones in response to microiontophoretic application of morphine largely coincides with the pattern of changes in impulsation in response to administration of leu-enkephalin rather than to met-enkephalin. Concurrent application of the subthreshold dose of enkephalins and morphine has revealed a possibility of the effects summation, the highest pharmacological activity being exhibited by leu-enkephalin combined with morphine. Selective blocking by enkephalins and morphine has been observed of evoked neuronal responses to peripheral exposures (ECS, stimulation of the sciatic nerve). Meanwhile the responses of cortical origin have been found to remain unchanged.
在对清醒猫的实验中已证实，中脑网状结构神经元的自发活动因微量离子电泳给予吗啡而发生的变化，在很大程度上与给予亮氨酸脑啡肽而非甲硫氨酸脑啡肽时冲动变化的模式相符。同时给予阈下剂量的脑啡肽和吗啡已显示出效应相加的可能性，亮氨酸脑啡肽与吗啡联合使用时表现出最高的药理活性。已观察到脑啡肽和吗啡对神经元对外周刺激（电惊厥刺激、坐骨神经刺激）诱发反应的选择性阻断作用。与此同时，发现皮质起源的反应保持不变。
