Kamburg R A, Zimakova I E
Farmakol Toksikol. 1982 Jul-Aug;45(4):16-9.
It was shown that the psychotropic agents diazepam (1-2 mg/kg), sodium hydroxybutyrate (50-100 mg/kg) and mebicar (250-500 mg/kg) exert a protective action in experimental arrhythmias. This effect is determined by the ability of the drugs to reduce intoxication phenomena, as well as by their antihypoxic and stress-protective properties. On the other hand, the drugs exert an antiarrhythmic effect proper, interfering with potassium ion balance. The protective effects of diazepam, sodium hydroxybutyrate and mebicar enable their application in combined therapy of arrhythmias of varying genesis.
结果表明,精神药物地西泮(1 - 2毫克/千克)、羟基丁酸钠(50 - 100毫克/千克)和美比卡(250 - 500毫克/千克)在实验性心律失常中发挥保护作用。这种作用取决于药物减轻中毒现象的能力,以及它们的抗缺氧和应激保护特性。另一方面,这些药物具有适当的抗心律失常作用,可干扰钾离子平衡。地西泮、羟基丁酸钠和美比卡的保护作用使其能够应用于不同病因心律失常的联合治疗。