Kulikova O N, Tarakanov A V
Farmakol Toksikol. 1982 Jul-Aug;45(4):52-4.
Protein fractions of the initial serum and acid-soluble proteins of the blood serum were examined in patients with acute myocardial infarction with marked pain syndrome before and after removal of the pain syndrome with fentanl and droperidol. It was noted that the total amount of protein in the initial serum and that of acid-soluble proteins were reduced as compared to the group of normal subjects. Disc electrophoresis demonstrated statistically significant differences in all the electrophoretic protein fractions of the initial blood serum. According to disc electrophoresis of acid-soluble proteins the greatest metabolic changes were experienced by proteins of the prealbumin zone. Three hours after the removal of the pain syndrome, protein metabolism did not return to normal. The intensity of quantitative changes in the disc electrophoretic zones remained at the same level as before the removal.
对患有急性心肌梗死且伴有明显疼痛综合征的患者,在使用芬太尼和氟哌利多消除疼痛综合征前后,检测其初始血清的蛋白质组分以及血清中的酸溶性蛋白质。结果发现,与正常受试者组相比,初始血清中的蛋白质总量以及酸溶性蛋白质的量均有所减少。圆盘电泳显示,初始血清的所有电泳蛋白质组分存在统计学上的显著差异。根据酸溶性蛋白质的圆盘电泳结果,前白蛋白区的蛋白质经历了最大的代谢变化。疼痛综合征消除三小时后,蛋白质代谢并未恢复正常。圆盘电泳区定量变化的强度仍维持在消除疼痛综合征之前的水平。