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胆碱能受体活性位点的分子要求。十八 - 环戊烯衍生物中活性与双键位置之间的相关性。

Molecular requirements of the active sites of the cholinergic receptors. XVIII-Correlation between activity and double bond position among cyclopentene derivatives.

作者信息

Brasili L, Leonelli M, Giannella M

出版信息

Farmaco Sci. 1982 Jul;37(7):431-7. doi: 10.1002/chin.198250144.

Abstract

Some cyclopentene derivatives lacking the oxygenated functions have been synthesized and tested as cholinergic compounds. Their good muscarinic potency seems to confirm that such compounds interact with a receptor area which is not coincident with that recognized by other cholinergic agents such as muscarine and deoxamuscarine.

摘要

一些缺乏氧化官能团的环戊烯衍生物已被合成并作为胆碱能化合物进行测试。它们良好的毒蕈碱活性似乎证实了这类化合物与一个受体区域相互作用,该区域与其他胆碱能药物(如毒蕈碱和脱氧毒蕈碱)所识别的区域不一致。

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