己酮可可碱对高渗条件下兔红细胞的细胞形态、ATP含量及变形性的影响。
Effects of pentoxifylline on cell shape, ATP content and deformability in rabbit erythrocytes under hyperosmolar conditions.
作者信息
Nishio T, Toshima Y, Matsuno Y
出版信息
Int J Biochem. 1982;14(10):915-20. doi: 10.1016/0020-711x(82)90075-1.
PMID:7128909
Abstract
- Pentoxifylline (I) [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] (0-10(-3) M) inhibited the discocyte echinocyte transformation caused by hyperosmolarity and improved the impaired filtrability of erythrocytes due to hyperosmolarity. 2. The ATP content of erythrocytes was increased at low concentrations (0-3 x 10(-5) M) of I, but decreased at high concentrations (3 x 10(-5) M or above) of I.
摘要
- 己酮可可碱（I）[3,7 - 二甲基 - 1 -（5 - 氧代己基）黄嘌呤]（0 - 10⁻³ M）可抑制高渗引起的盘状红细胞向棘状红细胞的转变，并改善因高渗导致的红细胞滤过性受损。2. 在低浓度（0 - 3×10⁻⁵ M）的I作用下，红细胞的ATP含量增加，但在高浓度（3×10⁻⁵ M及以上）的I作用下则降低。
相似文献
1
Effects of pentoxifylline on cell shape, ATP content and deformability in rabbit erythrocytes under hyperosmolar conditions.己酮可可碱对高渗条件下兔红细胞的细胞形态、ATP含量及变形性的影响。
Int J Biochem. 1982;14(10):915-20. doi: 10.1016/0020-711x(82)90075-1.
2
3
4
Effects of pentoxifylline on red blood cell deformability and blood viscosity under hyperosmolar conditions.己酮可可碱在高渗条件下对红细胞变形性和血液粘度的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Sep;299(2):197-200. doi: 10.1007/BF00498562.
5
[Assay of erythrocyte ATP by chemoluminescence. Protective action induced by pentoxifylline on the depletion of energy from stored erythrocytes].
Ric Clin Lab. 1985;15 Suppl 1:505-13.
6
The effect of pentoxifylline on the flow properties of human blood.
Curr Med Res Opin. 1978;5(8):608-13. doi: 10.1185/03007997809110195.
7
[Effect of hexobendine and pentoxifylline on the viscosity of erythrocyte suspension].
Wien Klin Wochenschr. 1983 Mar 18;95(6):209-13.
8
On the influence of pentoxifylline on the permeability of rat erythrocytes for methyl-O-glucose.
Arzneimittelforschung. 1979;29(5):757-60.
9
Effects of diltiazem on the physicochemical properties of rat erythrocyte and liposome membrane: comparison with pentoxifylline and propranolol.
Jpn J Pharmacol. 1984 Apr;34(4):417-27. doi: 10.1254/jjp.34.417.
10
Improvement of the flow properties of blood: a new therapeutical approach in occlusive arterial disease.
Angiology. 1976 Mar;27(3):188-96. doi: 10.1177/000331977602700306.
引用本文的文献
1
An Unusual Case of Hemolytic Anemia Reversed with Liver Transplantation.一例通过肝移植逆转的罕见溶血性贫血病例。
Int J Hematol Oncol Stem Cell Res. 2022 Apr 1;16(2):128-130. doi: 10.18502/ijhoscr.v16i2.9206.
2
Successful combination therapy--flunarizine, pentoxifylline, and cholestyramine--for spur cell anemia.成功的联合治疗——氟桂利嗪、己酮可可碱和消胆胺——用于棘状细胞贫血。
Int J Hematol. 2001 Apr;73(3):351-5. doi: 10.1007/BF02981961.
3
Cardioprotective actions of pentoxifylline in an animal model of acute myocardial ischaemia.己酮可可碱在急性心肌缺血动物模型中的心脏保护作用。
Br J Pharmacol. 1984 Apr;81(4):575-81. doi: 10.1111/j.1476-5381.1984.tb16121.x.
4
The effect of denbufylline on the viscosity of rat whole blood and on the deformability (filterability) of rat blood cell suspensions.
Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335(4):445-8. doi: 10.1007/BF00165561.
5
Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy.己酮可可碱。对其药效学和药代动力学特性以及治疗效果的综述。
Drugs. 1987 Jul;34(1):50-97. doi: 10.2165/00003495-198734010-00003.
Zotero 插件