己酮可可碱对高渗条件下兔红细胞的细胞形态、ATP含量及变形性的影响。
Effects of pentoxifylline on cell shape, ATP content and deformability in rabbit erythrocytes under hyperosmolar conditions.
作者信息
Nishio T, Toshima Y, Matsuno Y
出版信息
Int J Biochem. 1982;14(10):915-20. doi: 10.1016/0020-711x(82)90075-1.
PMID:7128909
Abstract
- Pentoxifylline (I) [3,7-dimethyl-1-(5-oxo-hexyl)-xanthine] (0-10(-3) M) inhibited the discocyte echinocyte transformation caused by hyperosmolarity and improved the impaired filtrability of erythrocytes due to hyperosmolarity. 2. The ATP content of erythrocytes was increased at low concentrations (0-3 x 10(-5) M) of I, but decreased at high concentrations (3 x 10(-5) M or above) of I.
摘要
- 己酮可可碱（I）[3,7 - 二甲基 - 1 -（5 - 氧代己基）黄嘌呤]（0 - 10⁻³ M）可抑制高渗引起的盘状红细胞向棘状红细胞的转变，并改善因高渗导致的红细胞滤过性受损。2. 在低浓度（0 - 3×10⁻⁵ M）的I作用下，红细胞的ATP含量增加，但在高浓度（3×10⁻⁵ M及以上）的I作用下则降低。
Zotero 插件