奥沙西泮半琥珀酸酯立体异构体对豚鼠脑突触体中[³H]腺苷结合的抑制作用。
Inhibition of [3H]adenosine binding by stereoisomers of oxazepam hemisuccinate in guinea-pig brain synaptosomes.
作者信息
DeLucia R
出版信息
Gen Pharmacol. 1982;13(4):357-9. doi: 10.1016/0306-3623(82)90059-3.
PMID:7129076
Abstract
- The stereoisomers of oxazepam sodium hemisuccinate have been tested for their ability to inhibit the [3H]adenosine binding in guinea-pig brain synaptosomes. 2. All three stereoisomers were able to inhibit the [3H]adenosine binding in a dose-dependent fashion. 3. The IC20 values of the D-, DL- and L-stereoisomers were approximately 5 X 10(-5) M, 7.5 X 10(-5) M and 10(-4) M respectively. 4. The results are consistent with hypothesis that adenosine may be the endogenous substrata mediating some actions of the benzodiazepines.
摘要
- 已对奥沙西泮半琥珀酸钠的立体异构体抑制豚鼠脑突触体中[3H]腺苷结合的能力进行了测试。2. 所有三种立体异构体均能以剂量依赖方式抑制[3H]腺苷结合。3. D-、DL-和L-立体异构体的IC20值分别约为5×10(-5)M、7.5×10(-5)M和10(-4)M。4. 这些结果与腺苷可能是介导苯二氮䓬类某些作用的内源性底物这一假设一致。
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