Beischer W
Fortschr Med. 1982 Sep 2;100(33):1508-12.
Chemistry, biochemistry and physiology of proinsulin and C-peptide are summarized. A short characterization of the radioimmunological methods for measuring C-peptide and proinsulin follows. The determination of C-peptide and proinsulin which was mainly carried out in serum or plasma essentially improved our knowledge about the function of the beta-cells in the islets of Langerhans in healthy subjects and diabetic patients. The paper reports on the occurrence and the course of C-peptide and proinsulin in healthy subjects and in diabetics of type I and II.
本文总结了胰岛素原和C肽的化学、生物化学及生理学特性。接下来简要介绍了测量C肽和胰岛素原的放射免疫方法。主要在血清或血浆中进行的C肽和胰岛素原测定，极大地增进了我们对健康受试者和糖尿病患者胰岛β细胞功能的了解。本文报道了健康受试者以及I型和II型糖尿病患者体内C肽和胰岛素原的出现情况及变化过程。
