Mendoza G R, Minagawa K
Int Arch Allergy Appl Immunol. 1982;69(3):282-4. doi: 10.1159/000233185.
Desensitization in human basophils was induced by suboptimal levels of antihuman IgE or antigen under normal calcium buffer conditions. Low doses of anti-IgE triggered only 0-12% histamine release during a 3-hour preincubation, yet initiated up to 100% desensitization upon rechallenge. After 24-27 h preincubation with allergen a, the cells did not regain releasability when rechallenged with either allergen a, allergen b or anti-IgE. Low dose, IgE-mediated desensitization in human basophils may lead to an irreversible and nonspecific inhibition of degranulation.
在正常钙缓冲条件下，次优水平的抗人IgE或抗原可诱导人嗜碱性粒细胞脱敏。低剂量抗IgE在3小时预孵育期间仅引发0-12%的组胺释放，但再次激发时可引发高达100%的脱敏。用过敏原a预孵育24-27小时后，当再次用过敏原a、过敏原b或抗IgE激发时，细胞未恢复释放能力。人嗜碱性粒细胞中低剂量IgE介导的脱敏可能导致脱颗粒的不可逆和非特异性抑制。
