Sostman H D, Neumann R D, Zoghbi S S, Lord P F, Thakur M L, Carbo P, Greenspan R H, Gottschalk A
Invest Radiol. 1982 Jul-Aug;17(4):367-74. doi: 10.1097/00004424-198207000-00011.
The effects of several potential modifiers on the detection of experimental pulmonary emboli by indium-111-labeled autologous platelets were studied. Contrast material did not affect embolus visualization; heparin prevented it, but its effect was not irreversible. The addition of exogenous thrombin to the experimental thrombus was not necessary for successful detection of the resulting emboli. Indium-111-oxine detected a small number of emboli without in vitro platelet labeling. Acutely embolized thrombi up to 72 hours old were readily identified by labeled platelets, but emboli older than 24 hours were almost impossible to detect. There was evidence suggesting propagation of emboli within the pulmonary arteries.
研究了几种潜在修饰剂对铟 - 111标记的自体血小板检测实验性肺栓塞的影响。造影剂不影响栓子显影；肝素可阻止其显影，但其作用并非不可逆。向实验性血栓中添加外源性凝血酶对于成功检测由此产生的栓子并非必要。铟 - 111 - 氧肟酸在未进行体外血小板标记的情况下检测到少量栓子。标记的血小板能够轻松识别高达72小时龄的急性栓塞血栓，但超过24小时的栓子几乎无法检测到。有证据表明栓子在肺动脉内会发生播散。
