溴化不透射线脂质体：用于肝脏和脾脏计算机断层扫描的造影剂：初步报告。

Brominated radiopaque liposomes: contrast agent for computed tomography of liver and spleen: a preliminary report.

作者信息

Caride V J, Sostman H D, Twickler J, Zacharis H, Orphanoudakis S C, Jaffe C C

出版信息

Invest Radiol. 1982 Jul-Aug;17(4):381-5.

Abstract

Contrast enhancement of liver and spleen in the dog was obtained after intravenous administration of brominated radioopaque liposomes (ROL) (1-5 micron in diameter. Computed tomographic (CT) numbers generated before and after 3 hours of ROL administration demonstrated an increase in hepatic attenuation. ROL are biodegradable lipid vesicles that can be subjected to further physicochemical modifications (size, charge composition) that alter their biodistribution and pharmacokinetics. These changes can result in improved hepatosplenic contrast enhancement.

摘要

在给狗静脉注射溴化不透射线脂质体（ROL，直径1 - 5微米）后，肝脏和脾脏出现了对比增强。在注射ROL 3小时前后生成的计算机断层扫描（CT）数值显示肝脏衰减增加。ROL是可生物降解的脂质囊泡，可进行进一步的物理化学修饰（大小、电荷组成），从而改变其生物分布和药代动力学。这些变化可导致肝脾对比增强改善。