Raghunathan Muthukumar, Kapoor Ashish, Kumar Praveen, Tripathi S C, Haque Shafiul, Pal Dan Bahadur
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu 603203 India.
Department of Chemical Engineering, Harcourt Butler Technical University, Kanpur, Uttar Pradesh 208002 India.
Indian J Microbiol. 2025 Mar;65(1):235-252. doi: 10.1007/s12088-024-01326-2. Epub 2024 Jul 26.
Nanofillers have emerged as versatile materials with immense potential in various biosensing and biotechnological applications, including tissue engineering, drug delivery, gene silencing, and biomedical imaging. This review explores the diverse types of nanofillers utilized in biosensors and biotechnological systems, their synthesis methods, classification, and their impact on enhancing the performance and functionality of biotechnological applications. The review delves into the intricate role of nanofillers in biosensors, investigating their influence on sensitivity, selectivity, and overall performance. It highlights their contributions to advancing diagnostic capabilities, biomarker detection, and real-time monitoring. Additionally, the review explores the integration of nanofillers in novel biosensing platforms, shedding light on their potential to revolutionize point-of-care diagnostics and personalized medicine. Further, discusses the challenges associated with nanofillers, such as toxicity and biocompatibility concerns, and provides insights into future directions and emerging trends in this rapidly evolving field. By comprehensively examining the synthesis, characterization, and performance enhancement strategies of nanofillers in multifarious biological applications. This review article aims to inspire further research and innovation for the development of advanced biotechnological systems.
纳米填料已成为具有多种用途的材料，在各种生物传感和生物技术应用中具有巨大潜力，包括组织工程、药物递送、基因沉默和生物医学成像。本综述探讨了用于生物传感器和生物技术系统的各种类型的纳米填料、它们的合成方法、分类，以及它们对提高生物技术应用的性能和功能的影响。该综述深入研究了纳米填料在生物传感器中的复杂作用，研究了它们对灵敏度、选择性和整体性能的影响。它强调了它们在推进诊断能力、生物标志物检测和实时监测方面的贡献。此外，该综述探讨了纳米填料在新型生物传感平台中的整合，揭示了它们在彻底改变即时诊断和个性化医疗方面的潜力。此外，还讨论了与纳米填料相关的挑战，如毒性和生物相容性问题，并对这一快速发展领域的未来方向和新趋势提供了见解。通过全面研究纳米填料在多种生物应用中的合成、表征和性能增强策略，本文旨在激发进一步的研究和创新，以开发先进的生物技术系统。
