颗粒细胞瘤的临床数据。
Clinical data of granulosa cell tumors.
作者信息
Schweppe K W, Beller F K
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):161-9. doi: 10.1007/BF00402064.
Abstract
Clinical data from Granulosa cell tumors (GCT) of the ovary were compared with data from 528 cases of malignant ovarian tumor in regard to symptomatology, treatment and prognosis. GCT are more frequent under the age of 30 and their biology requires a clinical separation from other feminizing mesenchymal tumors. Irregularities of uterine bleeding as a result of hormonal activity were the most frequent symptoms, explaining why their diagnosis is earlier than in ovarian cancer. The 5-year survival rates were similar when tumor stages were compared. GCT is associated with a frequency of late recurrences after 5, 10 or more years but a potential risk of malignancy is not related to clinical or histological criteria. Abdominal hysterectomy with bilateral salpingoophorectomy is standard treatment, whereas radiation and chemotherapy seem to be of little value.
摘要
将卵巢颗粒细胞瘤（GCT）的临床数据与528例恶性卵巢肿瘤的数据在症状、治疗和预后方面进行了比较。GCT在30岁以下更为常见，其生物学特性要求在临床上与其他女性化间叶组织肿瘤区分开来。激素活性导致的子宫出血不规律是最常见的症状，这解释了为何其诊断比卵巢癌更早。当比较肿瘤分期时，5年生存率相似。GCT与5年、10年或更长时间后的晚期复发频率相关，但恶性肿瘤的潜在风险与临床或组织学标准无关。腹式子宫切除术加双侧输卵管卵巢切除术是标准治疗方法，而放疗和化疗似乎价值不大。
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