用Walker 256癌肉瘤对大鼠进行抗凝治疗。
Anticoagulant treatment of rats with Walker 256 carcinosarcoma.
作者信息
Owen C A
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):191-3. doi: 10.1007/BF00402067.
Abstract
Various anticoagulant, antiplatelet, and fibrinolytic agents have been found to be effective in reducing metastatic growth of experimental animal tumors. This effectiveness is attributed to the requirement for hemostatic factors in the implantation and growth of metastases. However, clotting and platelet factors are also present at the site of a primary tumor, the Walker 256 carcinosarcoma. Yet maximally tolerated doses of heparin or warfarin did not affect the primary growth of this rat tumor.
摘要
已发现多种抗凝剂、抗血小板剂和纤维蛋白溶解剂在减少实验动物肿瘤的转移生长方面有效。这种有效性归因于转移灶植入和生长过程中对止血因子的需求。然而，凝血因子和血小板因子也存在于原发性肿瘤沃克256癌肉瘤的部位。然而，肝素或华法林的最大耐受剂量并不影响这种大鼠肿瘤的原发性生长。
相似文献
1
Anticoagulant treatment of rats with Walker 256 carcinosarcoma.
J Cancer Res Clin Oncol. 1982;104(1-2):191-3. doi: 10.1007/BF00402067.
2
Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.
Cochrane Database Syst Rev. 2017 Oct 2;10(10):CD012169. doi: 10.1002/14651858.CD012169.pub2.
3
Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid antibodies.
Cochrane Database Syst Rev. 2018 Jul 13;7(7):CD012534. doi: 10.1002/14651858.CD012534.pub2.
4
Pentasaccharides for the prevention of venous thromboembolism.
Cochrane Database Syst Rev. 2016 Oct 31;10(10):CD005134. doi: 10.1002/14651858.CD005134.pub3.
5
Antiplatelet versus anticoagulation treatment for people with heart failure in sinus rhythm.
Cochrane Database Syst Rev. 2025 Jun 11;6(6):CD003333. doi: 10.1002/14651858.CD003333.pub4.
6
WITHDRAWN: Anticoagulant and aspirin prophylaxis for preventing thromboembolism after major gynaecological surgery.
Cochrane Database Syst Rev. 2007 Jul 18;2003(4):CD003679. doi: 10.1002/14651858.CD003679.pub2.
7
Anticoagulant and aspirin prophylaxis for preventing thromboembolism after major gynaecological surgery.
Cochrane Database Syst Rev. 2003(4):CD003679. doi: 10.1002/14651858.CD003679.
8
Antiplatelet agents and anticoagulants for hypertension.
Cochrane Database Syst Rev. 2011 Dec 7;2011(12):CD003186. doi: 10.1002/14651858.CD003186.pub3.
9
Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy.
Cochrane Database Syst Rev. 2016 Dec 1;12(12):CD008500. doi: 10.1002/14651858.CD008500.pub4.
10
Primary prophylaxis for venous thromboembolism in people undergoing major amputation of the lower extremity.
Cochrane Database Syst Rev. 2013 Dec 16(12):CD010525. doi: 10.1002/14651858.CD010525.pub2.
引用本文的文献
1
Can LMWH improve the outcome of patients with inoperable stage III non-small cell lung cancer?
Contemp Oncol (Pozn). 2012;16(5):416-9. doi: 10.5114/wo.2012.31771. Epub 2012 Nov 20.
2
Antiangiogenic activity of orally absorbable heparin derivative in different types of cancer cells.
Pharm Res. 2009 Dec;26(12):2667-76. doi: 10.1007/s11095-009-9989-9. Epub 2009 Oct 15.
3
Impact of venous thromboembolism and anticoagulation on cancer and cancer survival.
J Clin Oncol. 2009 Oct 10;27(29):4902-11. doi: 10.1200/JCO.2009.22.4584. Epub 2009 Sep 8.
4
Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity.
J Cancer Res Clin Oncol. 1988;114(5):507-8. doi: 10.1007/BF00391501.
本文引用的文献
1
The response of serum ceruloplasmin to injections of walker 256 tumor cells or turpentine into rats.
Biol Trace Elem Res. 1981 Sep;3(3):217-24. doi: 10.1007/BF02990118.
2
Effect of Walker 256 tumor or turpentine on hemostatic factors locally and generally in rats.
Eur J Cancer Clin Oncol. 1981 Aug;17(8):919-24. doi: 10.1016/0014-2964(81)90315-7.
3
Hypersensitivity to warfarin in rats with Walker 256 carcinoma.
Proc Soc Exp Biol Med. 1982 Jan;169(1):1-3. doi: 10.3181/00379727-169-41297.
4
5
Effect of warfarin on survival in small cell carcinoma of the lung. Veterans Administration Study No. 75.
JAMA. 1981 Feb 27;245(8):831-5.
6
Rationale and experimental design for the VA Cooperative Study of Anticoagulation (Warfarin) in the Treatment of Cancer.
Cancer. 1979 Aug;44(2):732-41. doi: 10.1002/1097-0142(197908)44:2<732::aid-cncr2820440246>3.0.co;2-y.
Zotero 插件