用Walker 256癌肉瘤对大鼠进行抗凝治疗。
Anticoagulant treatment of rats with Walker 256 carcinosarcoma.
作者信息
Owen C A
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):191-3. doi: 10.1007/BF00402067.
Abstract
Various anticoagulant, antiplatelet, and fibrinolytic agents have been found to be effective in reducing metastatic growth of experimental animal tumors. This effectiveness is attributed to the requirement for hemostatic factors in the implantation and growth of metastases. However, clotting and platelet factors are also present at the site of a primary tumor, the Walker 256 carcinosarcoma. Yet maximally tolerated doses of heparin or warfarin did not affect the primary growth of this rat tumor.
摘要
已发现多种抗凝剂、抗血小板剂和纤维蛋白溶解剂在减少实验动物肿瘤的转移生长方面有效。这种有效性归因于转移灶植入和生长过程中对止血因子的需求。然而，凝血因子和血小板因子也存在于原发性肿瘤沃克256癌肉瘤的部位。然而，肝素或华法林的最大耐受剂量并不影响这种大鼠肿瘤的原发性生长。
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本文引用的文献
1
The response of serum ceruloplasmin to injections of walker 256 tumor cells or turpentine into rats.血清铜蓝蛋白对大鼠注射 walker 256 肿瘤细胞或松节油的反应。
Biol Trace Elem Res. 1981 Sep;3(3):217-24. doi: 10.1007/BF02990118.
2
Effect of Walker 256 tumor or turpentine on hemostatic factors locally and generally in rats.Walker 256肿瘤或松节油对大鼠局部和全身止血因子的影响。
Eur J Cancer Clin Oncol. 1981 Aug;17(8):919-24. doi: 10.1016/0014-2964(81)90315-7.
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Hypersensitivity to warfarin in rats with Walker 256 carcinoma.
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