Miyauchi Y, Isomura K
J Cardiovasc Surg (Torino). 1982 Sep-Oct;23(5):383-90.
Platelet count, ADP-aggregation and adhesiveness of platelets, fibrinogen, FDP, and prothrombin time were examined in 50 patients who had undergone open cardiac surgery. Ticlopidine (250 mg/day) and Dipyridamole (1-2 mg/day) were administered prior to the extracorporeal circulation and the platelet inhibitory effects were compared. Platelet count was reduced markedly with the initiation of bypass and the low level was maintained until the 3rd postoperative day. Hyperthrombocythemia was found after a week. ADP induced platelet aggregation and platelet adhesiveness were markedly depressed by the ACC. Fibrinogen showed low level during the ECC but the hyper-fibrinogenemic state was observed in postoperative course. FDP showed an abnormally high value in nearly half the cases, particularly in the cases of valvular replacement. Ticlopidine markedly depressed the ADP-aggregation and Dipyridamole reduced platelet adhesiveness and thus both drugs showed a prophylactic effect in the reduction of platelets.
对50例接受心脏直视手术的患者进行了血小板计数、血小板的二磷酸腺苷（ADP）聚集和黏附性、纤维蛋白原、纤维蛋白降解产物（FDP）及凝血酶原时间的检测。在体外循环前给予噻氯匹定（250毫克/天）和双嘧达莫（1 - 2毫克/天），并比较其对血小板的抑制作用。在体外循环开始时血小板计数显著降低，且低水平一直维持到术后第3天。术后一周出现血小板增多症。ADP诱导的血小板聚集和血小板黏附性被ACC显著抑制。在体外循环期间纤维蛋白原水平较低，但在术后过程中观察到高纤维蛋白原血症状态。近一半的病例中FDP值异常高，尤其是在瓣膜置换病例中。噻氯匹定显著抑制ADP聚集，双嘧达莫降低血小板黏附性，因此两种药物在减少血小板方面均显示出预防作用。
