Ratcliffe S G, Field M A
J Child Psychol Psychiatry. 1982 Oct;23(4):401-6. doi: 10.1111/j.1469-7610.1982.tb00086.x.
Four boys, from a group of fourteen with an XYY chromosome constitution identified by cytogenetic screening at birth, were referred for psychiatric treatment, age seven to nine years. Presenting symptoms included severe temper tantrums, stealing and enuresis, and they were diagnosed as having mild to severe emotional disorders. There were multiple factors of increased risk for psychiatric disturbance in their backgrounds nd there was evidence of reactive depression in all four boys. Treatment with individual and family psychotherapy, combined with antidepressant medication in two of the four children and special educational provisions in one, resulted in good short-term outcome comparable to that achieved in chromosomally normal boys.
在出生时通过细胞遗传学筛查确定的14名具有XYY染色体构成的男孩中，有4名男孩在7至9岁时被转介接受精神治疗。他们表现出的症状包括严重的发脾气、偷窃和尿床，被诊断患有轻度至重度情绪障碍。他们的背景中有多种导致精神障碍风险增加的因素，并且所有4名男孩都有反应性抑郁的迹象。通过个体和家庭心理治疗，4名儿童中有2名联合使用抗抑郁药物，1名接受特殊教育，取得了良好的短期效果，与染色体正常的男孩相当。
