Goldberg M J, Spector R, Johnson G F
J Clin Pharmacol. 1982 Aug-Sep;22(8-9):391-4. doi: 10.1002/j.1552-4604.1982.tb02691.x.
The pharmacokinetics of lidocaine were investigated in 17 healthy young adult volunteers seven Caucasians, five Orientals, and five Blacks). With the assumption of a one-compartment open model and linear pharmacokinetics, analysis of the data determined that there were no significant differences in the volume of distribution, clearance, elimination half-life, and serum protein binding of lidocaine among these racial groups. Our finding that lidocaine clearance and protein binding are not significantly different in young adult Caucasians and Orientals is consistent with our previous hypothesis that drugs metabolized in the body by N-dealkylation (lidocaine and diphenhydramine) area cleared at similar rates in young adult Caucasians and Orientals when protein binding is taken into account.
在17名健康的年轻成年志愿者（7名高加索人、5名东方人和5名黑人）中研究了利多卡因的药代动力学。假设为单室开放模型和线性药代动力学，对数据进行分析后确定，这些种族群体之间利多卡因的分布容积、清除率、消除半衰期和血清蛋白结合率没有显著差异。我们发现，年轻成年高加索人和东方人利多卡因的清除率和蛋白结合率没有显著差异，这与我们之前的假设一致，即当考虑蛋白结合时，在年轻成年高加索人和东方人身体中通过N-脱烷基化代谢的药物（利多卡因和苯海拉明）清除率相似。
