老年期的生理变化：与药物处置改变的关系。

Physiologic changes in old age: relation to altered drug disposition.

作者信息

Greenblatt D J, Divoll M, Abernethy D R, Shader R I

出版信息

J Am Geriatr Soc. 1982 Nov;30(11 Suppl):S6-10. doi: 10.1111/j.1532-5415.1982.tb01350.x.

DOI:10.1111/j.1532-5415.1982.tb01350.x

Abstract

Current knowledge of the effects of aging on drug disposition is reviewed. Although definitive studies are not always available, based on present evidence it appears that: 1) drug absorption is not impaired in the elderly; 2) drug distribution in the elderly may be altered by significant changes in the lipid/lean body mass ratio; 3) Phase I (non-synthetic) biotransformation reactions of the liver appear to be much more profoundly affected by aging than are Phase II (synthetic) reactions; 4) age-related effects of biotransformation can be different even for compounds that are very similar and undergo the same types of reactions. Important parameters of drug metabolism are also discussed, such as the need to use total clearance, rather than half-life, in assessing pharmacokinetics.

摘要

本文综述了目前关于衰老对药物处置影响的知识。尽管并非总能获得确凿的研究，但根据现有证据，似乎：1）老年人的药物吸收未受损；2）老年人的药物分布可能因脂质/瘦体重比的显著变化而改变；3）肝脏的I相（非合成）生物转化反应似乎比II相（合成）反应受衰老的影响更为深刻；4）即使对于非常相似且经历相同类型反应的化合物，生物转化的年龄相关影响也可能不同。还讨论了药物代谢的重要参数，例如在评估药代动力学时需要使用总清除率而非半衰期。