无毛小鼠表皮中的晒伤细胞：紫外线A辐射以及单功能和双功能补骨脂素的定量研究

The sunburn cell in hairless mouse epidermis: quantitative studies with UV-A radiation and mono- and bifunctional psoralens.

作者信息

Young A R, Magnus I A

出版信息

J Invest Dermatol. 1982 Oct;79(4):218-21. doi: 10.1111/1523-1747.ep12500064.

Abstract

The production of the sunburn cell by UV-A radiation and topical psoralens in hairless mouse epidermis has been studied. It has been shown that the appearance of this cell is dependent on the dose of both UV-A radiation and of the psoralen. The time-course with 8-methoxypsoralen has peak sunburn cell numbers at 28 hr postirradiation. A comparison of 2 bifunctional (8-methoxypsoralen and 5-methoxypsoralen) and 2 monofunctional (angelicin and 3-carbethoxypsoralen) psoralens showed the former are more potent. This suggests that DNA crosslink lesions may play a rle in sunburn cell production.

摘要

已经研究了紫外线A辐射和局部补骨脂素在无毛小鼠表皮中产生晒伤细胞的情况。结果表明，这种细胞的出现取决于紫外线A辐射和补骨脂素的剂量。8-甲氧基补骨脂素的时间进程显示，在照射后28小时晒伤细胞数量达到峰值。对2种双功能补骨脂素（8-甲氧基补骨脂素和5-甲氧基补骨脂素）和2种单功能补骨脂素（当归素和3-乙氧羰基补骨脂素）的比较表明，前者更有效。这表明DNA交联损伤可能在晒伤细胞的产生中起作用。