Koulischer L, Schoysman R, Gillerot Y
J Genet Hum. 1982 Jun;30(2):81-99.
Meiotic chromosome studies in male infertility are controversial: some authors find them useful, others do not. Indeed, interpretation of data already published is still difficult, for some main reasons discussed in the text: the small volume of testicular tissue available for observation, the lack of uniformity in the selection of patients from series to series, the presentation of the results. Nevertheless, critical analysis of the literature leads to the conclusion that in 10% of patients whom underwent testicular biopsy, meiotic chromosome anomalies can easily explain their infertility. Our personal series of 450 cases confirms this order of magnitude. Therefore, we think that meiotic chromosome analysis is certainly useful in the evaluation of male infertility, both for diagnosis and prognosis.
一些作者认为它们有用,另一些则不然。事实上,由于文本中讨论的一些主要原因,对已发表数据的解释仍然困难:可供观察的睾丸组织量少,系列之间患者选择缺乏一致性,结果呈现方式。然而,对文献的批判性分析得出结论,在接受睾丸活检的患者中,有10%的减数分裂染色体异常可以很容易地解释其不育症。我们个人的450例病例系列证实了这个数量级。因此,我们认为减数分裂染色体分析在评估男性不育症方面肯定有用,无论是用于诊断还是预后。