沙鼠水杨酸盐耳毒性：行为学与电子显微镜研究

Salicylate ototoxicity in the chinchilla: a behavioral and electron microscope study.

作者信息

Deer B C, Hunter-Duvar I

出版信息

J Otolaryngol. 1982 Aug;11(4):260-4.

Abstract

Normal audiograms were obtained from a group of behaviorally conditioned chinchillas. Following this the animals were injected with sodium salicylate. Temporary hearing losses were measured 1 1/2 hours after treatment. Animals were anesthetized and blood samples taken to determine salicylate levels. The animals were then decapitated and the temporal bones were examined by SEM and TEM. No morphological correlate was seen for temporary hearing losses which were generally in the neighborhood of 30-40 dB.

摘要

从一组经过行为条件训练的毛丝鼠身上获得了正常听力图。在此之后，给这些动物注射了水杨酸钠。在治疗后1个半小时测量了暂时性听力损失。对动物进行麻醉并采集血样以测定水杨酸盐水平。然后将动物断头，并通过扫描电子显微镜（SEM）和透射电子显微镜（TEM）检查颞骨。未发现与通常在30 - 40分贝左右的暂时性听力损失相关的形态学特征。