非霍奇金淋巴瘤组织学亚型中的独特染色体异常。

Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma.

作者信息

Yunis J J, Oken M M, Kaplan M E, Ensrud K M, Howe R R, Theologides A

出版信息

N Engl J Med. 1982 Nov 11;307(20):1231-6. doi: 10.1056/NEJM198211113072002.

DOI:10.1056/NEJM198211113072002

Abstract

Using a new high-resolution technique for chromosomal analysis, we have successfully studied biopsy specimens of lymph nodes from 42 of 44 patients with non-Hodgkin's lymphoma and have categorized them using the new international histologic formulation and immunologic markers. Abnormalities of the clonal chromosomes were detected in all 42 patients. Three recurrent chromosomal aberrations were found to correlate with certain histologic types: a translocation between chromosomes 18 and 14 in 16 of 19 patients with follicular lymphomas (small cleaved cell, mixed cell, and large cell); a translocation between chromosomes 8 and 14 in 5 of 6 patients with small noncleaved-cell (non-Burkitt's) or large-cell immunoblastic lymphoma; and a trisomy 12 in 4 of 11 patients with small-cell lymphocytic lymphoma. Our findings suggest that characteristic chromosomal defects occur in certain lymphoma subtypes and that high-resolution chromosomal analysis promises to become an important tool in improving our basic understanding of lymphoid cancers.

摘要

利用一种用于染色体分析的新型高分辨率技术，我们成功地研究了44例非霍奇金淋巴瘤患者中42例的淋巴结活检标本，并使用新的国际组织学分类法和免疫标记物对其进行了分类。在所有42例患者中均检测到克隆染色体异常。发现三种复发性染色体畸变与某些组织学类型相关：19例滤泡性淋巴瘤（小裂细胞型、混合细胞型和大细胞型）中的16例存在18号和14号染色体之间的易位；6例小无裂细胞（非伯基特氏）或大细胞免疫母细胞性淋巴瘤中的5例存在8号和14号染色体之间的易位；11例小细胞淋巴细胞性淋巴瘤中的4例存在12号染色体三体性。我们的研究结果表明，某些淋巴瘤亚型存在特征性染色体缺陷，高分辨率染色体分析有望成为增进我们对淋巴癌基本认识的重要工具。