人类金属硫蛋白基因——金属硫蛋白-II基因及一个相关加工基因的一级结构

Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene.

作者信息

Karin M, Richards R I

出版信息

Nature. 1982 Oct 28;299(5886):797-802. doi: 10.1038/299797a0.

Abstract

The complete nucleotide sequence of two of the human metallothionein gene family has been compared. One is a functional metallothionein-II gene, the other a pseudogene, lacking introns, terminating in a poly(A) tail and flanked by two direct repeats. In addition, we have detected a size polymorphism associated with the processed gene in the population, examined, and we have observed a region of apparent secondary structure homology between of 5' flanking region of the functional metallothionein-II gene and that of a mouse metallothionein-I gene.

摘要

已对人类金属硫蛋白基因家族中的两个基因的完整核苷酸序列进行了比较。一个是功能性金属硫蛋白-II基因，另一个是假基因，没有内含子，以聚腺苷酸尾结尾，并由两个同向重复序列侧翼。此外，我们在群体中检测到与加工基因相关的大小多态性，并进行了检查，而且我们观察到功能性金属硫蛋白-II基因的5'侧翼区域与小鼠金属硫蛋白-I基因的5'侧翼区域之间存在明显的二级结构同源区域。