Bianucci P, Pastorino G, Brondi P
Minerva Med. 1982 Oct 27;73(41):2891-5.
55 patients with various types of malignant neoplasias at different stages were given DNCB skin tests in the Oncological Department of the S. Paolo Hospital in Savona. Lymphocyte blastisation was evaluated both before and after the skin test. In about 75% of the patients it was observed that DNCB sensitisation increased lymphocyte blastisation capacity independently of the level of reaction to the skin test, the type of neoplasia or the patients' age. Indeed increased blatisation was more noticeable in non-responsive DNCB. The hypothesis is advanced that DNCB has the capacity indirectly to stimulate blastisation by unknown mechanisms.
在萨沃纳的圣保罗医院肿瘤科,对55例处于不同阶段的各类恶性肿瘤患者进行了二硝基氯苯(DNCB)皮肤试验。在皮肤试验前后均对淋巴细胞转化进行了评估。在约75%的患者中观察到,DNCB致敏作用可提高淋巴细胞转化能力,且与皮肤试验反应程度、肿瘤类型或患者年龄无关。实际上,在对DNCB无反应的患者中,淋巴细胞转化增加更为明显。有人提出假说,认为DNCB能够通过未知机制间接刺激淋巴细胞转化。