流感氧化铝吸附疫苗与水性疫苗的抗原性及耐受性比较。

Comparison of the antigenicity and tolerance of an influenza aluminium oxide adsorbate vaccine with an aqueous vaccine.

作者信息

Pressler K, Peukert M, Schenk D, Borgoño M

出版信息

Pharmatherapeutica. 1982;3(3):195-200.

Abstract

A randomized trial was carried out in 189 adult subjects to test the antigenicity and tolerance of two experimental influenza vaccines, one adsorbed onto aluminium oxide and the other one aqueous, with equal antigen contents. Blood samples for antibody assays, using the haemagglutination inhibition test and the neuraminidase inhibition test, were taken before and 30, 90 and 180 days after vaccination. The results showed that the adsorbate influenza vaccine had a superior immunogenic action to the aqueous vaccine at the same dose rate. There were no significant differences between the tolerances of the two vaccines, which were injected with a needle. About 81% of the vaccinated subjects showed no subjective or objective signs of intolerance. Systemic reactions, which were reported by 9% of the vaccinated subjects, were verified by the doctor in only 2% of cases.

摘要

对189名成年受试者进行了一项随机试验，以测试两种实验性流感疫苗的抗原性和耐受性，一种吸附于氧化铝上，另一种为水性疫苗，两种疫苗抗原含量相同。在接种疫苗前以及接种后30天、90天和180天采集血样，采用血凝抑制试验和神经氨酸酶抑制试验进行抗体检测。结果表明，在相同剂量率下，吸附型流感疫苗的免疫原性优于水性疫苗。两种通过注射接种的疫苗在耐受性方面没有显著差异。约81%的接种受试者未出现不耐受的主观或客观迹象。9%的接种受试者报告了全身反应，但医生仅在2%的病例中证实了这些反应。