巴比妥类药物化学：分离薄层色谱鉴定及反应机制
Barbiturate chemistry: separation TLC identification and mechanism of reaction.
作者信息
Fiorese F, Vermuelen G, Turcotte C
出版信息
Subst Alcohol Actions Misuse. 1982;3(1-2):61-76.
Thin layer chromatography and chemical detection procedures for barbiturates are described and the reaction mechanism introduced. We show that by this technique barbiturates can be characterized as long, intermediate, short, and very short acting, with a few exceptions, by Rf value and by the typical spot color hue. The factors involved and chemical requirements for color are mentioned, e.g. 1. Behavior in organic solvents 2. Silica Gel polarity and pH 3. Functional groups responsible for interaction with the reagent 4. pH and chemicals of the color developer 5. Mechanism of reaction.
本文描述了巴比妥类药物的薄层色谱法和化学检测程序，并介绍了反应机制。我们表明，通过该技术，除少数例外情况外，巴比妥类药物可根据比移值（Rf值）和典型斑点颜色色调分为长效、中效、短效和超短效类。文中提到了相关因素以及显色的化学要求，例如：1. 在有机溶剂中的行为；2. 硅胶的极性和pH值；3. 与试剂相互作用的官能团；4. 显色剂的pH值和化学成分；5. 反应机制。
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