Law M R, Henk J M, Lennox S C, Hodson M E
Thorax. 1982 Jul;37(7):496-9. doi: 10.1136/thx.37.7.496.
Two groups have been selected from 1000 patients who had lobectomy or pneumonectomy for bronchial carcinoma. The first group was of 26 patients with tumour affecting the mucosa of the resected bronchial margin reported histologically at the time of surgery. Twelve of these were given postoperative radiotherapy but with no apparent benefit, either in the incidence of recurrence of tumour at the bronchial stump or in five-year survival. The second group was of 17 patients who developed recurrence of tumour at the bronchial stump, bronchoscopically confirmed, some time after surgery. In six of these cases the recurrence was detected while it was confined to the bronchial stump region, and these patients were then given radiotherapy. Five of the six survived five years after radiotherapy, with complete eradication of the tumour recurrence confirmed by repeat bronchoscopy. In 11 cases the tumour recurrence was not detected until it had become more extensive. Radiotherapy may also have prolonged survival in some of these patients, although none survived five years.
从1000例因支气管癌接受肺叶切除术或全肺切除术的患者中选取了两组。第一组有26例患者,其肿瘤侵犯了手术时经组织学报告的切除支气管切缘黏膜。其中12例接受了术后放疗,但无论是在支气管残端肿瘤复发率还是五年生存率方面,均未显示出明显益处。第二组有17例患者,术后一段时间经支气管镜证实支气管残端出现肿瘤复发。在其中6例病例中,复发局限于支气管残端区域时被检测到,这些患者随后接受了放疗。6例患者中有5例在放疗后存活了五年,经重复支气管镜检查证实肿瘤复发已完全消除。在11例病例中,肿瘤复发直到范围扩大时才被检测到。放疗可能也延长了其中一些患者的生存期,尽管无人存活五年。