Glazko A J, Peterson F E, Chang T, Dill W A, Smith T C, Buchanan R A
Ther Drug Monit. 1982;4(3):281-92. doi: 10.1097/00007691-198208000-00006.
Normal adult men with long and short phenytoin plasma half-lives were given 300-mg oral doses of phenytoin once daily for 15 days. Plasma levels of phenytoin (DPH) and its major metabolite (p-HPPH) were measured during the period of drug administration and for 5 days thereafter. Average steady-state plasma levels of DPH rose to 13.4 micrograms/ml in the long half-life group, compared with 3.6 micrograms/ml in the short half-life group. HPPH levels in the long half-life group were about one half of those observed in the short half-life group. The DPH/HPPH ratios in plasma specimens showed excellent correlation with the plasma half-lives of DPH and average steady-state levels, suggesting that this ratio could provide guidance in the selection of optimum dosage regimens for problem patients.
将苯妥英血浆半衰期长和短的正常成年男性每天口服300毫克苯妥英，持续15天。在给药期间及之后5天测量苯妥英（DPH）及其主要代谢物（p-HPPH）的血浆水平。在长半衰期组中，DPH的平均稳态血浆水平升至13.4微克/毫升，而短半衰期组为3.6微克/毫升。长半衰期组中的HPPH水平约为短半衰期组中观察到的水平的一半。血浆标本中的DPH/HPPH比值与DPH的血浆半衰期和平均稳态水平显示出极好的相关性，这表明该比值可为问题患者选择最佳给药方案提供指导。
