Hiepe F, Apostoloff E, Döring E, Kuhlmey J, Taubert M
Z Alternsforsch. 1982 Jul-Aug;37(4):227-31.
The circulating immune complexes were quantitatively determined by PEG-precipitation in the serum samples of 413 from the clinical point of view healthy persons subdivided into several age groups. In comparison with the other age groups the age group of 0-15 years showed the lowest immune complex values (mean = 3.14 +/- 0.96 mg protein/ml) with a significant higher distribution (p = 5%). Significant differences between the persons of the age of 16-30, 31-45 and 46-60 years were not traceable. The average values of the circulating immune complexes amounted to 3.82 +/- 0.75, 3.9 +/- 0.67 respectively 3.91 +/- 0.38 mg protein/ml. In comparison with these three age groups the circulating immune complexes showed with an average value of 3.62 +/- 0.75 mg protein/ml a falling tendency for the persons more than 60 years old. There existed a statistical significant difference (p = 5%) for the persons of the age of 31-45 years. A sexual dependence of the immune complexes could not be found within the age groups. Autoantibodies (ANF, anti-dsDNA antibodies) were traceable in the serum of 23 (24.7%) of the persons more than 60 years old. The comparison of the sera with and without autoantibodies didn't show any significant difference with regard to the immune complexes.
采用聚乙二醇沉淀法对413名临床视角下的健康人血清样本中的循环免疫复合物进行了定量测定，这些健康人被分为几个年龄组。与其他年龄组相比，0至15岁年龄组的免疫复合物值最低（平均值 = 3.14 +/- 0.96毫克蛋白/毫升），分布显著更高（p = 5%）。16至30岁、31至45岁和46至60岁人群之间未发现显著差异。循环免疫复合物的平均值分别为3.82 +/- 0.75、3.9 +/- 0.67和3.91 +/- 0.38毫克蛋白/毫升。与这三个年龄组相比，60岁以上人群的循环免疫复合物平均值为3.62 +/- 0.75毫克蛋白/毫升，呈下降趋势。31至45岁人群存在统计学显著差异（p = 5%）。在各年龄组内未发现免疫复合物存在性别依赖性。在60岁以上人群的血清中可检测到自身抗体（抗核因子、抗双链DNA抗体），占23人（24.7%）。有自身抗体和无自身抗体的血清在免疫复合物方面未显示出任何显著差异。
