Hoberg E, Lemke R, Klaus D
Z Kardiol. 1982 Aug;71(8):544-8.
The relationship between R-wave amplitude and left ventricular volume was studied in four tests, each including six normal adults. The means of 10 heart cycles of the R-wave amplitude in surface ECG lead V5 (RV5) and the echocardiographically determined left ventricular enddiastolic dimension (LVEDD) were compared before and during different interventions. After inhalation of 0.3 ml isoamylnitrit, LVEDD was reduced to 7.7%, RV5 to 15.0% below control. During a maneuver of Valsalva, LVEDD decreased to 8.6%, RV5 to 12.9% below control. In both tests heart rates increased markedly. After oral application of propranolol (0.7 to 1.0 mg/kg) LVEDD did not change, whereas RV5 decreased to 8.2% below control. During rapid intravenous infusion of 1 l NaCl 0.9% in 10 to 15 minutes, LVEDD increased to 15.7% above control. R-wave amplitude remained constant. Thus the results of these last two tests let us doubt whether the Brody-effect can be translated without limitation on the in-vivo situation in man.
在四项试验中研究了R波振幅与左心室容积之间的关系，每项试验包括六名正常成年人。比较了体表心电图V5导联（RV5）中R波振幅10个心动周期的平均值与经超声心动图测定的左心室舒张末期内径（LVEDD）在不同干预前后的情况。吸入0.3ml亚硝酸异戊酯后，LVEDD降至比对照低7.7%，RV5降至比对照低15.0%。在瓦尔萨尔瓦动作期间，LVEDD降至比对照低8.6%，RV5降至比对照低12.9%。在这两项试验中，心率均显著增加。口服普萘洛尔（0.7至1.0mg/kg）后，LVEDD未改变，而RV5降至比对照低8.2%。在10至15分钟内快速静脉输注1升0.9%氯化钠溶液期间，LVEDD增加至比对照高15.7%。R波振幅保持不变。因此，这最后两项试验的结果让我们怀疑布罗迪效应是否能毫无限制地应用于人体的体内情况。
