卡马西平对血清免疫球蛋白浓度的影响。

The effect of carbamazepine on serum immunoglobulin concentrations.

作者信息

Gilhus N E, Strandjord R E, Aarli J A

出版信息

Acta Neurol Scand. 1982 Aug;66(2):172-9. doi: 10.1111/j.1600-0404.1982.tb04514.x.

DOI:10.1111/j.1600-0404.1982.tb04514.x

Abstract

Serum IgA, IgG and IgM concentrations were determined in 30 patients with partial epilepsy before and during carbamazepine therapy. None of them had received anti-epileptic drugs prior to the study. The IgA and IgM concentrations decreased significantly during the 1st month of treatment (P less than 0.0001). No further decrease was observed during the subsequent 3 months. 15 patients were followed for 8-30 months. The IgA concentrations remained low, while the IgM concentrations tended to increase. However, the IgM concentrations did not reach the levels which were found before carbamazepine was started. Carbamazepine had no influence on the mean IgG serum concentration. There was no relationship between the IgA and IgM concentrations in serum and the serum concentrations of carbamazepine.

摘要

测定了30例部分性癫痫患者在卡马西平治疗前及治疗期间的血清IgA、IgG和IgM浓度。在研究之前，他们均未接受过抗癫痫药物治疗。治疗第1个月期间，IgA和IgM浓度显著下降（P<0.0001）。在随后的3个月中未观察到进一步下降。15例患者随访了8至30个月。IgA浓度持续偏低，而IgM浓度有升高趋势。然而，IgM浓度未达到开始使用卡马西平之前的水平。卡马西平对血清平均IgG浓度无影响。血清中IgA和IgM浓度与卡马西平的血清浓度之间无相关性。