接受卡马西平治疗的癫痫患者血清免疫球蛋白浓度

Serum of concentrations of immunoglobulins in patients with epilepsy treated with carbamazepine.

作者信息

Strandjord R E, Johannessen S I, Aarli J A

出版信息

Acta Neurol Scand. 1980 Apr;61(4):260-3. doi: 10.1111/j.1600-0404.1980.tb01491.x.

DOI:10.1111/j.1600-0404.1980.tb01491.x

Abstract

The concentrations of IgA, IgG and IgM were determined in sera of 16 patients, all of whom had partial epilepsy and had received CBZ as the only drug since the beginning of therapy. Fifty-three healthy subjects served as controls. Serum concentrations of IgA and IgG were significantly higher in patients than in controls (IgA: P = 0.05; IgG: P = 0.01). The concentration of IgM was not significantly different from that of the controls (P = 0.1). The IgG serum levels in the controls were lower with increasing age. Furthermore, IgG serum levels were higher with increasing CBZ concentrations.

摘要

测定了16例部分性癫痫患者血清中IgA、IgG和IgM的浓度，所有患者自治疗开始以来均接受卡马西平（CBZ）作为唯一药物治疗。53名健康受试者作为对照。患者血清中IgA和IgG的浓度显著高于对照组（IgA：P = 0.05；IgG：P = 0.01）。IgM的浓度与对照组无显著差异（P = 0.1）。对照组中IgG血清水平随年龄增长而降低。此外，IgG血清水平随CBZ浓度升高而升高。