Wang R Y, Tse T F, Yu D Y, Lee P K, Sum M S, Chow M S
Am Heart J. 1982 Nov;104(5 Pt 1):1016-21. doi: 10.1016/0002-8703(82)90434-3.
The hemodynamic effects of terbutaline infusion at rates of 0.15, 0.3, and 0.45 micrograms/kg/min were studied and compared in eight patients with severe heart failure. Terbutaline infusion at 0.15 micrograms/kg/min infusion produced insignificant effects at 30 minutes. At 0.3 micrograms/kg/min infusion highly significant beneficial hemodynamic effects were observed: at 60 minutes cardiac index increased from 1.79 +/- 0.38 to 3.60 +/- 0.96 (mean +/- SD) L/min/m2 (p less than 0.0001) and stroke volume index increased from 20.1 +/- 6.2 to 36.7 +/- 13.1 ml/beat/m2 (p less than 0.0001); mean pulmonary artery wedge pressure fell from 27.5 +/0- 5.5 to 18.5 +/- 5.7 mm Hg (p less than 0.0001); systemic vascular resistance fell from 2624 +/- 586 to 1455 +/- 500 dynes . sec . cm-5/m2 (p less than 0.0001); and pulmonary vascular resistance fell from 248 +/- 84 to 150 +/- 70 dynes . sec . cm-5/m2 (p less than 0.0005). Mean arterial pressure and O2 uptake did not change significantly; however, mean heart rate increased from 93.4 +/- 22 to 103.1 +/- 26 bpm (p less than 0.005) and plasma potassium fell from 3.86 +/- 0.14 to 3.12 +/ 0.23 mEq/L (p less than 0.05). The 0.45 micrograms/kg/min infusion at 30 minutes produced no greater hemodynamic changes than that from 0.3 micrograms/kg/min. Our study suggests that intravenous terbutaline produces beneficial effects and may be useful in the acute management of severe heart failure.
在8例严重心力衰竭患者中研究并比较了以0.15、0.3和0.45微克/千克/分钟的速率输注特布他林的血流动力学效应。以0.15微克/千克/分钟的速率输注特布他林在30分钟时产生的效应不显著。以0.3微克/千克/分钟的速率输注时观察到非常显著的有益血流动力学效应：在60分钟时，心脏指数从1.79±0.38增加到3.60±0.96（均值±标准差）升/分钟/平方米（p<0.0001），每搏量指数从20.1±6.2增加到36.7±13.1毫升/次/平方米（p<0.0001）；平均肺动脉楔压从27.5±5.5降至18.5±5.7毫米汞柱（p<0.0001）；全身血管阻力从2624±586降至1455±500达因·秒·厘米-5/平方米（p<0.0001）；肺血管阻力从248±84降至150±70达因·秒·厘米-5/平方米（p<0.0005）。平均动脉压和氧摄取没有显著变化；然而，平均心率从93.4±22增加到103.1±26次/分钟（p<0.005），血浆钾从3.86±0.14降至3.12±0.23毫当量/升（p<0.05）。在30分钟时以0.45微克/千克/分钟的速率输注产生的血流动力学变化并不比以0.3微克/千克/分钟的速率输注时更大。我们的研究表明，静脉注射特布他林产生有益效应，可能对严重心力衰竭的急性处理有用。
