Criqui M H, Klauber M R, Barrett-Connor E, Holdbrook M J, Suarez L, Wingard D L
Am J Epidemiol. 1982 Oct;116(4):685-91. doi: 10.1093/oxfordjournals.aje.a113451.
To evaluate the validity and implications of using various obesity indices in adjusting or controlling for obesity, correlations were analyzed between six cardiovascular disease risk factors, age, cholesterol, log triglyceride, systolic blood pressure, diastolic blood pressure, and fasting plasma glucose, and weight (W), height (H), and five commonly used obesity indices, W/H, W/H2, 3 square root W/H, -H/3 square root W, and relative weight in a defined population of 4956 men and women. Subjects were residents of Rancho Bernardo, California and were surveyed in 1972-1974. Correlations of weight, height, and the obesity indices were also evaluated with each other. W/H, 3 square root W/H, and -H/3 square root W were highly correlated with weight (correlations = 0.96-0.997), but also correlated with height (correlations = 0.10-0.48). These very high correlations with weight and moderate correlations with height resulted in risk factor correlations with these three indices reflecting weight-risk factor correlations rather than obesity-risk factor correlations. W/H2 and relative weight were not quite so highly correlated with weight (correlations = 0.83-0.89), very highly correlated with each other (correlations = 0.999), and relatively uncorrelated with height (correlations = 0.17-0.01). W/H2 and relative weight risk factor correlations reflected true obesity-risk factor correlations and were significantly greater than risk factor correlations with weight, W/H, 3 square root W/H, and -H/3 square root W. These data strongly support the use of either W/H2 or relative weight for obesity adjustment in cardiovascular disease studies. Use of W/H, 3 square root W/H, or -H/3 square root W may result in underadjustment for obesity.
为评估使用各种肥胖指数来调整或控制肥胖的有效性及影响，在一个由4956名男性和女性组成的特定人群中，分析了六种心血管疾病风险因素（年龄、胆固醇、甘油三酯对数、收缩压、舒张压和空腹血糖）与体重（W）、身高（H）以及五个常用肥胖指数（W/H、W/H²、³√W/H、-H/³√W和相对体重）之间的相关性。研究对象为加利福尼亚州兰乔贝纳多的居民，于1972年至1974年接受了调查。还评估了体重、身高和肥胖指数之间的相互关系。W/H、³√W/H和-H/³√W与体重高度相关（相关性 = 0.96 - 0.997），但也与身高相关（相关性 = 0.10 - 0.48）。这些与体重的极高相关性以及与身高的中等相关性导致这些三个指数与风险因素的相关性反映的是体重 - 风险因素相关性，而非肥胖 - 风险因素相关性。W/H²和相对体重与体重的相关性没那么高（相关性 = 0.83 - 0.89），彼此之间相关性极高（相关性 = 0.999），与身高的相关性相对较低（相关性 = 0.17 - 0.01）。W/H²和相对体重与风险因素的相关性反映了真正的肥胖 - 风险因素相关性，且显著大于与体重、W/H、³√W/H和-H/³√W的风险因素相关性。这些数据有力地支持在心血管疾病研究中使用W/H²或相对体重进行肥胖调整。使用W/H、³√W/H或-H/³√W可能导致对肥胖的调整不足。
